贝类遗传与演化研究室
连姗姗
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连姗姗

连姗姗

博士,副教授,硕士生导师

中国海洋大学“青年英才”第三层次

研究领域:海洋模式贝类、基因编辑和干细胞调控研究

联系方式:

教育经历

2004-2008, 中国海洋大学海洋生命学院,生物科学,学士

2008-2013,中国海洋大学海洋生命学院,海洋生物学,博士

工作经历

2013-2017,美国斯普里克斯研究所(Scripps,FL,USA),Metabolism & Aging,博士后

2017-2020,中国海洋大学海洋生命学院,博士后

2020至今,中国海洋大学,海洋生命学院,副教授

主要研究方向及成果

主要从事功能基因组学研究,近年来主要在针对动物发育、进化等生物学过程的分子调控机制解析及重要性状相关基因的功能研究方面取得了重要的成果,发表在包括AutophagyPNASNature Ecology & Evolution等在内的国际知名期刊上。

主持项目

1. 中国海洋大学“青年英才工程”科研启动经费,30万

2. 国家自然科学基金青年基金:32002373,24万

3. 国家实验室“渔业青年科技人才”:2018-MFS-T06,25万

代表性成果(#共同第一;*通讯作者)

  1. Wang J(#), Zhang L(#), Lian S(#), Qin Z(#), Zhu X(#), Dai X, Huang Z, Ke C, Zhou Z, Wei J, Liu P, Hu N, Zeng Q, Cui C, Dong B, Dong Y, Kong D, Zhang Z, Liu S, Xia Y, Li Y, Zhao L, Xing Q, Huang X, Hu X, Bao Z, Wang S(*) (2020). Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae. Nature Ecology & Evolution: 1-12. IF: 15.460
  2. Sasaki T(#), Lian S(#), Khan A, Llop J, Samuelson A, Chen W, Klionsky D and Kishi S(*) (2017). Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy 13(2): 386-403. IF: 16.016
  3. Song Y(#), Shi Y(#), Carland T, Lian S, Sasaki T, Schork N , Head S, Kishi S(*) and Schimmel P(*) (2016). p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish. Proceedings of the National Academy of Sciences of the United States of America 113(30): 8460-8465. IF: 11.205
  4. Sasaki T, Lian S, Qi J, Bayliss P, Carr C, Johnson J, Guha S, Kobler P, Catz S, Gill M, Jia K, Klionsky D and Kishi S(*) (2014). Aberrant Aautolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. Plos Genetics 10(6). IF: 5.917
  5. Wang Y(#), Zhu X(#), Lian S(*), Li Y, Hu N, Hu X, Bao Z and Wang S (2022). Functional characterization of Cfap206 for bivalve ciliogenesis by RNAi and CRISPR/Cas9 technologies. Frontiers in Marine ScienceIF: 4.912
  6. Lian S(#), Zhao L(#), Xun X, Lou J, Li M, Li X, Wang S, Zhang L, Hu X(*) and Bao Z (2019). Genome-wide identification and characterization of SODs in Zhikong scallop reveals gene expansion and regulation divergence after toxic dinoflagellate exposure. Marine Drugs 17(12): 700. IF: 5.11
  7. Hu N, Lian S(*), Zhu X, Chen X, Sun F, Zhang L, Wang S, Bao Z, Hu J(*) (2022). Interferon regulatory factors functioned as activators of the interferon pathway in the scallop Chlamys farreri. Frontiers in Marine Science 9:865707. IF: 4.912
  8. Chen X(#), Hu N(#), Lian S(*), Li L, Sun F, Zhang L, Wang S, Bao Z, Hu J(*). (2022) Genome-wide identification and expression profiling of COMMD gene family in four bivalve molluscs. Frontiers in Marine Science. 9: 884991. IF: 4.912
  9. Xu K(#), Wang Y(#), Lian S(*),Hu N, Chen X, Dai X, Zhang L, Wang X, JHu J, Hu X, Bao Z (2021). Expansion of C1Q genes in Zhikong scallop and their expression profiling after exposure to the toxic dinoflagellates. Frontiers in Marine ScienceIF: 4.912
  10. Zhu X(#), Zhang F(#), Lian S(*), Wang Y, Hu N, Chen X, Dai X, Hu X, Wang S, Bao Z (2021). IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate. Frontiers in PhysiologyIF: 4.566
  11. Zhao L(#), Lian S(#), en Q, Yang Z, Guo Z, Lou J, Kong X, Li M, Bao Z, Hu X(*)(2021). In vivo and rapid assessment of scallop muscle trait. AquacultureIF: 4.242
  12. Lian S(#), Wang J(#), Zhang L, Xing Q, Hu N, Liu S, Dai X, Zhang F, Hu X, Bao Z and Wang S(*) (2019). Integration of biochemical, cellular, and genetic indicators for understanding the aging process in a bivalve mollusk Chlamys farreri. Marine Biotechnology 21: 718-730. IF: 3.619
  13. Zhao L(#), Li Y(#), Lou J, Yang Z, Liao H, Fu Q, Guo Z, Lian S(*), Hu X and Bao Z (2019). Transcriptomic profiling provides insights into inbreeding depression in Yesso scallop Patinopecten yessoensisMarine Biotechnology 21: 623-633. IF: 3.619
  14. Li X(#), Wang S(#), Xun X, Zhang M, Wang S, Li H, Zhao L, Fu Q, Wang H, Li T, Lian S, Xing Q, Li X, Wu W, Zhang L, Hu X(*) and Bao Z (2019). A carotenoid oxygenase is responsible for muscle coloration in scallop. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(7): 966-975. IF: 4.698
  15. Li Y, Wang R, Xun X, Wang J, Bao L, Thimmappa R, Ding J, Jiang J, Zhang L, Li T, Lv J, Mu C, Hu X, Zhang L, Liu J, Li Y, Yao L, Jiao W, Wang Y, Lian S, Zhao Z, Zhan Y, Huang X, Liao H, Wang J, Sun H, Mi X, Xia Y, Xing Q, Lu W, Osbourn A, Zhou Z(*), Chang Y(*), Bao Z(*), and Wang S(*) (2018). Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation. Cell Discovery, 4:29. IF: 10.849
  16. Liu S(#), Chen X(#), Lian S(*), Dai X, Hu N, Zhang F, Zhang L, Bao Z and Wang S (2018). Genome-wide identification and expression profiling of the Wnt gene family in three bivalve molluscs. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 29: 299-307.