贝类遗传与演化研究室
李语丽
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李语丽

李语丽

博士,教授,博士生导师

中国海洋大学“青年英才”第一层次

研究领域:海洋贝类基因组学和适应性演化研究

联系方式:

教育经历

2005-2009,山东农业大学生命科学学院,生物工程专业,学士

2009-2012,中国科学院北京基因组研究所,基因组学专业,硕士

2012-2015,中国科学院北京基因组研究所,生物信息学专业,博士

工作经历

2015-2018,中国海洋大学海洋生命学院,贝类基因组学,博士后

2019-2022,中国海洋大学海洋生命学院,“青年英才”工程第三层次,副教授

2022至今,中国海洋大学海洋生命学院,“青年英才”工程第一层次,教授

主要研究方向

主要从事贝类基因组学研究,聚焦在三个方面:1)贝类进化与适应的分子基础解析;2)贝类综合数据库的构建;3)组学技术的研发与利用。

主持项目

1. 国家自然科学基金优秀青年基金:贝类基因组学(32222085),2023.01-2025.12,200万,项目负责人

2. 中国海洋大学优秀青年科技人才培育计划A类,2023.01-2025.12,100万,项目负责人

3. 中国海洋大学优秀青年科技人才培育计划B类,2021.01-2022.12,50万,项目负责人

4. 中国海洋大学“青年英才工程”科研启动经费,2019.06–2021.06,30万,项目负责人

5. 国家自然科学基金青年基金:扇贝闭壳肌“分子杂合”特征的遗传调控基础解析(31702330),2018.01–2020.12,25万,项目负责人

代表性成果(#共同第一,*通讯作者)

  1. Wei J#, Liu P#, Liu F#, Jiang A, Qiao J, Pu Z, Wang B, Zhang J, Jia D, Li Y*, Wang S*, Dong B*. EDomics: a comprehensive and comparative multi-omics database for animal evo-devo. Nucleic Acids Research, 2023, 51(D1): D913–D923.
  2. Li Y#, Liu Y#, Yu H, Liu F, Han W, Zeng Q, Zhang Y, Zhang L, Hu J, Bao Z & Wang S*. Adaptive bird-like genome miniaturization during the evolution of scallop swimming lifestyle. Genomics, Proteomics & Bioinformatics, 2022, 20: 1066-1077. (Cover Story)
  3. Han W#, Liu L#, Wang J#, Wei H#, Li Y#, Zhang L#, Guo Z, Li Y, Liu T, Zeng Q, Xing Q, Shu Y, Wang T, Yang Y, Zhang M, Li R, Yu J, Pu Z, Lv J, Lian S, Hu J, Hu X, Bao Z, Bao L*, Zhang L*, Wang S*. (2022) Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution. 6: 1891-1906. (Cover Story; Behind the Paper: The 'forever-young' secret of scallop sex chromosomes: exceptions to the 'general' rules)

  4. Liu F, Li Y*, Yu H, Zhang L, Hu J, Bao Z and Wang S*. MolluscDB: an integrated functional and evolutionary genomics database for the hyper-diverse animal phylum Mollusca. Nucleic Acids Research, 2021, 49(D1): D988-D997.
  5. Wang J#, Yu H#, Yao L#Li Y*, Liu F, Han W, Cui C, Hu J, Bao Z and Wang S*. Genomic and transcriptomic landscapes and evolutionary dynamics of molluscan glycoside hydrolase families with implications for algae-feeding biology. Computational and Structural Biotechnology Journal, 2020, 18: 2744-2756.
  6. Li Y#, Sun X#, Hu X#, Jiao W#, Xun X#, Zhang J#, Guo X#, Zhang L, Liu W, Wang J, Li J, Sun Y, Miao Y, Cheng T, Xu GL, Fu X, Wang Y, Yu X, Huang X, Lu W, Lv J, Mu C, Wang D, Li X, Xia Y, Li YP, Yang Z, Wang F, Zhang L, Xing Q, Dou H, Ning X, Dou J, Li Y, Kong D, Liu Y, Jiang Z, Li R, Wang S& Bao Z*, Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins, Nature Communications, 2017, 8:1721.
  7. Li Y#, Wang R#, Xun X#, Wang J#, Bao L#, Thimmappa R#, Ding J#, Jiang J#, Zhang L, Li T, Lv J, Mu C, Hu X, Zhang L, Liu J, Li Y, Yao L, Jiao W, Wang Y, Lian S, Zhao Z, Zhan Y, Huang X, Liao H, Wang J, Sun H, Mi X, Xia Y, Xing Q, Lu W, Osbourn A, Zhou Z*, Chang Y*, Bao Z* & Wang S*. Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation, Cell Discovery, 2018, 4: 29.
  8. Li Y#, Wang X#, Chen T#, Yao F, Li C, Tang Q, Sun M, Sun G, Hu S, Yu J, Song S*, RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem, Plos One, 2015, 10(5): e0125722.
  9. Li Y#, Song S#,*, Wang X, Li C, Hu S, Yu J, Transcriptome-wide N(6)-methyladenosine profiling of rice callus and leaf reveals the presence of tissue-specific competitors involved in selective mRNA modification, RNA Biology, 2014, 11(9): 1180-1188.
  10. Li Y, Song S*, Li C, Yu J, MeRIP-PF: an easy-to-use pipeline for high-resolution peak-finding in MeRIP-Seq data, Genomics Proteomics Bioinformatics, 2013, 11(1):72-75.
  11. Wang S#, Zhang J#, Jiao W#, Li J#, Xun X#, Sun Y#, Guo X#, Huan P #, Dong B, Zhang L, Hu X, Sun X, Wang J, Zhao C, Wang Y, Wang D, Huang X, Wang R, Lv J, Li Y, Zhang Z, Liu B, Lu W, Hui Y, Liang J, Zhou Z, Hou R, Li X, Liu Y, Li H, Ning X, Lin Y, Zhao L, Xing Q, Dou J, Li YP, Mao J, Guo H, Dou H, Li T, Mu C, Jiang W, Fu Q, Fu X, Miao Y, Liu J, Yu Q, Li R, Liao H, Li X, Kong Y, Jiang Z, Chourrout D*, Li R* & Bao Z*, Scallop genome provides insights into evolution of bilaterian karyotype and development, Nature Ecology & Evolution, 2017, 1(5):120.
  12. Dou J#, Dou H#, Mu C, Zhang L, Li Y, Wang J, Li T, Li Y, Hu X, Wang S*, Bao Z*, Whole-genome restriction mapping by “subhaploid”-based RAD sequencing: an efficient and flexible approach for physical mapping and genome scaffolding, Genetics, 2017, 206: 1237~1250.
  13. Wang X#, Song S#,*, Wu Y#Li Y, Chen T, Huang Z, Liu S, Dunwell T, Pfeifer G, Dunwell J, Wamaedeesa R, Ullah I, Wang Y, Hu S*, Genome-wide mapping of 5-hydroxymethylcytosine in three rice cultivars reveals its preferential localization in transcriptionally silent transposable element genes, Journal of Experimental Botany, 2015, 66(21): 6651-6663.

授权专利

1. 包振民,李语丽,王师,刘雅然,陆维. LAS1基因在皂苷高产型海参选育中的应用. 批准号:201810542803.8