贝类遗传与演化研究室
吕佳
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吕佳

吕佳

博士,副教授,硕士生导师

中国海洋大学 "青年英才" 第三层次

研究领域:组学技术研发和贝类单细胞组学研究

联系方式:

教育经历

2006-2010, 中国海洋大学,生物科学专业,学士

2010-2013, 中国海洋大学,海洋生物学专业,硕士

2017-2020, 中国海洋大学,遗传学专业,博士

工作经历

2013-2017, 中国海洋大学,研究助理

2020-2022, 中国海洋大学,方宗熙-萨斯海洋分子生物学研究中心,博士后

2022至今,中国海洋大学,副教授

主要研究方向及成果

主要从事组学技术方法的开发及应用。成功研发了一系列低成本、高通量的基因分型技术,突破了长期以来全基因组分型技术流程繁琐而且费用过高等技术瓶颈,取得了一系列有国际影响力的成果。文章发表在Genome Research、Engineering、Open Biology、Aquaculture等期刊。参与编写专著《Bioinformatics in Aquaculture: Principles and Methods》。

主持项目

1. 国家自然科学基金青年基金,32102778

2. 中国博士后科学基金面上项目,2021M693024

3. 山东省博士后创新项目

代表性成果(#共同一作,*通讯作者)

  1. Lv J#, Wang Y#,*, Ni P, Lin P, Hou H, Ding J*, Chang Y*, Hu J*, Wang S, Bao Z. Development of a high-throughput SNP array for sea cucumber (Apostichopus japonicus) and its application in genomic selection with MCP regularized deep neural networks. Genomics. 2022, 114: 110426.
  2. Liu P#Lv J#,*, Ma C, Zhang T, Huang X, Yang Z, Zhang L, Hu J, Wang S, Bao Z*. Targeted genotyping of a whole-gene repertoire by an ultrahigh-multiplex and flexible HD-Marker approachEngineering. 2022, 13: 186-196.
  3. Lv J#, Cai Y#, Liu P, Huang X, Lv Z, Zhang R, Zhao L, Bao L, Wang S, Hu J*. Genomic differentiation and selection signatures of two elite varieties of Yesso scallop Mizuhopecten yessoensis. Aquaculture2022, 550: 737842.
  4. Sun Z#, Huang S#,*, Zhu P, Tzehau L, Zhao H, Lv J, Zhang R, Zhou L, Niu Q, Wang X, Zhang M, Jing G, Bao Z, Liu J, Wang S*, Xu J*. Species-resolved sequencing of low-biomass or degraded microbiomes using 2bRAD-M. Genome Biology. 2022, 23: 36. (AAAS EurekAlert News)
  5. Wang H#Lv J#, Zeng Q*, Liu Y, Xing Q, Wang S, Hu J, Bao L*. Genetic differentiation and selection signatures in two bay scallop (Argopecten irradians) breeds revealed by whole-genome resequencing analysis. Aquaculture. 2021, 543: 736944.
  6. Lv J#, Jiao W#, Guo H#, Liu P, Wang R, Zhang L, Zeng Q, Hu X, Bao Z, Wang S*. HD-Marker: a highly multiplexed and flexible approach for targeted genotyping of more than 10,000 genes in a single-tube assay. Genome Research2018, 28: 1919-1930.
  7. Xu T#, Sun J#, Lv J, Watanabe H, Li T, Zou W, Rouse GW, Wang S, Qian PY*, Bao Z*, Qiu JW*. Genome-wide discovery of single nucleotide polymorphisms (SNPs) and single nucleotide variants (SNVs) in deep-sea mussels: Potential use in population genomics and cross-species application. Deep-Sea Research II. 2017, 137: 318-326.
  8. Wang S*,#, Liu P#, Lv J, Li Y, Cheng T, Zhang L, Xia Y, Sun H, Hu X, Bao Z*. Serial sequencing of isolength RAD tags for cost-efficient genome-wide profiling of genetic and epigenetic variations. Nature Protocols. 2016, 11: 2189-2200.
  9. Wang S#Lv J#, Zhang L#, Dou J, Sun Y, Li X, Fu X, Dou H, Mao J, Hu X, Bao Z*. MethylRAD: a simple and scalable method for genome-wide DNA methylation profiling using methylation-dependent restriction enzymes. Open Biology. 2015, 5: 150130.